Signe Davida Augusta Hesse-Lilienberg (1877–1964) was a Swedish operatic soprano. She made her debut at the Royal Swedish Opera in 1904 as Zerlina in Mozart's Don Giovanni. Until 1909, she performed leading soprano roles for the company, gaining popularity thanks to her strong, wide-ranging voice and her effective stagecraft. She is remembered in particular for the title role in Puccini's Madame Butterfly which she first performed at the Swedish premiere in August 1908. After her marriage in 1910, she continued to appear occasionally as a guest performer at the opera as well as in recitals. In 1921, she was elected a member of the Royal Swedish Academy of Music.